A system for quantifying the patterning of the lymphatic vasculature.
Identifieur interne : 007351 ( Main/Exploration ); précédent : 007350; suivant : 007352A system for quantifying the patterning of the lymphatic vasculature.
Auteurs : Ramin Shayan [Australie] ; Tara Karnezis ; Evelyn Tsantikos ; Steven P. Williams ; Andrew S. Runting ; Mark W. Ashton ; Marc G. Achen ; Margaret L. Hibbs ; Steven A. StackerSource :
- Growth factors (Chur, Switzerland) [ 0897-7194 ] ; 2007.
Descripteurs français
- KwdFr :
- Animaux, Cicatrisation de plaie, Facteur de croissance endothéliale vasculaire de type C (physiologie), Facteur de croissance endothéliale vasculaire de type D (physiologie), Lymphangiogenèse, Modèles animaux, Peau (métabolisme), Peau (traumatismes), Souches mutantes de souris, Souris, Tumeurs expérimentales (anatomopathologie), Tumeurs expérimentales (métabolisme), Vaisseaux lymphatiques (anatomie et histologie), Vaisseaux lymphatiques (anatomopathologie), Vaisseaux lymphatiques (embryologie).
- MESH :
- anatomie et histologie : Vaisseaux lymphatiques.
- anatomopathologie : Tumeurs expérimentales, Vaisseaux lymphatiques.
- embryologie : Vaisseaux lymphatiques.
- métabolisme : Peau, Tumeurs expérimentales.
- physiologie : Facteur de croissance endothéliale vasculaire de type C, Facteur de croissance endothéliale vasculaire de type D.
- traumatismes : Peau.
- Animaux, Cicatrisation de plaie, Lymphangiogenèse, Modèles animaux, Souches mutantes de souris, Souris.
English descriptors
- KwdEn :
- Animals, Lymphangiogenesis, Lymphatic Vessels (anatomy & histology), Lymphatic Vessels (embryology), Lymphatic Vessels (pathology), Mice, Mice, Mutant Strains, Models, Animal, Neoplasms, Experimental (metabolism), Neoplasms, Experimental (pathology), Skin (injuries), Skin (metabolism), Vascular Endothelial Growth Factor C (physiology), Vascular Endothelial Growth Factor D (physiology), Wound Healing.
- MESH :
- chemical , physiology : Vascular Endothelial Growth Factor C, Vascular Endothelial Growth Factor D.
- anatomy & histology : Lymphatic Vessels.
- embryology : Lymphatic Vessels.
- injuries : Skin.
- metabolism : Neoplasms, Experimental, Skin.
- pathology : Lymphatic Vessels, Neoplasms, Experimental.
- Animals, Lymphangiogenesis, Mice, Mice, Mutant Strains, Models, Animal, Wound Healing.
Abstract
The lymphatic vasculature is critical for immunity and interstitial fluid homeostasis, playing important roles in diseases such as lymphedema and metastatic cancer. Animal models have been generated to explore the role of lymphatics and lymphangiogenic growth factors in such diseases, and to study lymphatic development. However, analysis of lymphatic vessels has primary been restricted to counting lymphatics in two-dimensional tissue slices, due to a lack of more sophisticated methodologies. In order to accurately examine lymphatic dysfunction in these models, and analyse the effects of lymphangiogenic growth factors on the lymphatic vasculature, it is essential to quantify the morphology and patterning of the distinct lymphatic vessels types in three-dimensional tissues. Here, we describe a method for performing such analyses, integrating user-operated image-analysis software with an approach that considers important morphological, anatomical and patterning features of the distinct lymphatic vessel subtypes. This efficient, reproducible technique is validated by analysing healthy and pathological tissues.
DOI: 10.1080/08977190801932550
PubMed: 18365872
Affiliations:
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Williams</name></author><author><name sortKey="Runting, Andrew S" sort="Runting, Andrew S" uniqKey="Runting A" first="Andrew S" last="Runting">Andrew S. Runting</name></author><author><name sortKey="Ashton, Mark W" sort="Ashton, Mark W" uniqKey="Ashton M" first="Mark W" last="Ashton">Mark W. Ashton</name></author><author><name sortKey="Achen, Marc G" sort="Achen, Marc G" uniqKey="Achen M" first="Marc G" last="Achen">Marc G. Achen</name></author><author><name sortKey="Hibbs, Margaret L" sort="Hibbs, Margaret L" uniqKey="Hibbs M" first="Margaret L" last="Hibbs">Margaret L. Hibbs</name></author><author><name sortKey="Stacker, Steven A" sort="Stacker, Steven A" uniqKey="Stacker S" first="Steven A" last="Stacker">Steven A. 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Animal models have been generated to explore the role of lymphatics and lymphangiogenic growth factors in such diseases, and to study lymphatic development. However, analysis of lymphatic vessels has primary been restricted to counting lymphatics in two-dimensional tissue slices, due to a lack of more sophisticated methodologies. In order to accurately examine lymphatic dysfunction in these models, and analyse the effects of lymphangiogenic growth factors on the lymphatic vasculature, it is essential to quantify the morphology and patterning of the distinct lymphatic vessels types in three-dimensional tissues. Here, we describe a method for performing such analyses, integrating user-operated image-analysis software with an approach that considers important morphological, anatomical and patterning features of the distinct lymphatic vessel subtypes. This efficient, reproducible technique is validated by analysing healthy and pathological tissues.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Achen, Marc G" sort="Achen, Marc G" uniqKey="Achen M" first="Marc G" last="Achen">Marc G. Achen</name><name sortKey="Ashton, Mark W" sort="Ashton, Mark W" uniqKey="Ashton M" first="Mark W" last="Ashton">Mark W. Ashton</name><name sortKey="Hibbs, Margaret L" sort="Hibbs, Margaret L" uniqKey="Hibbs M" first="Margaret L" last="Hibbs">Margaret L. Hibbs</name><name sortKey="Karnezis, Tara" sort="Karnezis, Tara" uniqKey="Karnezis T" first="Tara" last="Karnezis">Tara Karnezis</name><name sortKey="Runting, Andrew S" sort="Runting, Andrew S" uniqKey="Runting A" first="Andrew S" last="Runting">Andrew S. Runting</name><name sortKey="Stacker, Steven A" sort="Stacker, Steven A" uniqKey="Stacker S" first="Steven A" last="Stacker">Steven A. Stacker</name><name sortKey="Tsantikos, Evelyn" sort="Tsantikos, Evelyn" uniqKey="Tsantikos E" first="Evelyn" last="Tsantikos">Evelyn Tsantikos</name><name sortKey="Williams, Steven P" sort="Williams, Steven P" uniqKey="Williams S" first="Steven P" last="Williams">Steven P. Williams</name></noCountry><country name="Australie"><noRegion><name sortKey="Shayan, Ramin" sort="Shayan, Ramin" uniqKey="Shayan R" first="Ramin" last="Shayan">Ramin Shayan</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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